I agree with Kennith about verifying the head gasket first.
Have you done a compression test (dry then wet)?
Have you done a leak down test?
Not to try to try to scare you but, I was having a lot of trouble with misfires on #7 for a few months. It was also after a seafoam treatment, but probably just coincidental.
The misfires continued (even to the point of the MIL flashing at times) until the #7 rod broke. I never figured out what the exact cause was, but what I found was the piston skirt was in the oil pan with the wrist pin as well as the top half of the rod, while the pisotn deck remained in the cylinder.
While the sleeve/liner did not appear to be out of position, it was pretty damaged from the lower half of the rod (remaining on the crank) banging around before I could kill the engine.
Like I said, I don't want to scare you, but your story sounds a bit familiar. I think it may be worth some exploratory surgery to find out what is wrong.
You would probably like the 4.6 (even without the cam), but you may save yourself some serious headache (and money), if you just tear into your existing motor before something major happens. As you are putting it all back together, you can decide on a few performance upgrades that make it seem even more worthwhile. I really don't see a reason to get crazy with ideas of Chevy engines or diesel engines etc. You would end up spending WAY more time and money.
If it were me, I would line up a second vehicle for a month or two, and tear into the motor. Hopefully, you have a garage to do this (especially with the cold).
With the RAVE CD, supplemented by others on this board, you will learn a boat load.
We can talk you through it.
I suppose you could get a independent shop to do this for you , but it will obviously cost much more.
I know it sucks, but I hope this helps a bit.
Peace,
Dan