You can't really say that gasoline contents are more aggressive than alcohol. They're both aggressive, but in different ways. Something that could live happily for a lifetime with alcohol in it, could be destroyed quickly with gasoline, and vice versa. Modern cars are generally constructed of materials resistant to both, but they aren't really designed for E85 levels of alcohol, and long term use could be a problem.
The most important, instant issue with running E85 is that if the fuel injectors and pump don't have enough headroom, they will not be able to richen up the mixture enough to run on E85 which requires something like 50% more volumetric flow than straight gas.
Normally , they try to size the injectors as small as possible for emissions and NVH reasons. Larger injectors are less accurate at idle, and noise as hell. You can hear the 42's on my Focus over and above the flat-tappet-lifters-DOHC-and-plastic-valve-cover noise.