The salient points:
Our intricate, informal system of political intermediation, which took many decades to build, did not commit suicide or die of old age; we reformed it to death. For decades, well-meaning political reformers have attacked intermediaries as corrupt, undemocratic, unnecessary, or (usually) all of the above. Americans have been busy demonizing and disempowering political professionals and parties, which is like spending decades abusing and attacking your own immune system. Eventually, you will get sick.
The disorder has other causes, too: developments such as ideological polarization, the rise of social media, and the radicalization of the Republican base. But chaos syndrome compounds the effects of those developments, by impeding the task of organizing to counteract them. Insurgencies in presidential races and on Capitol Hill are nothing new, and they are not necessarily bad, as long as the governing process can accommodate them. Years before the Senate had to cope with Ted Cruz, it had to cope with Jesse Helms. The difference is that Cruz shut down the government, which Helms could not have done had he even imagined trying.
Like many disorders, chaos syndrome is self-reinforcing. It causes governmental dysfunction, which fuels public anger, which incites political disruption, which causes yet more governmental dysfunction.